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BN40665R-100ul
100ul
￥2360.00
交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40665R-200ul
200ul
￥3490.00
交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱(chēng) | TIMP-2 |
| 中文名稱(chēng) | 金屬蛋白酶組織抑制因子-2抗體 |
| 別 名 | Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2. |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 生長(zhǎng)因子和激素 合成與降解 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIMP-2:141-220/220 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]. Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Subunit: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP2 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P16035 Gene ID: 7077 Database links: Entrez Gene: 100135629 Guinea pig Entrez Gene: 7077 Human Entrez Gene: 21858 Mouse Entrez Gene: 100008689 Rabbit Omim: 188825 Human SwissProt: Q9WUC6 Guinea pig SwissProt: P16035 Human SwissProt: P25785 Mouse SwissProt: Q9TRZ7 Rabbit Unigene: 633514 Human Unigene: 206505 Mouse Unigene: 10161 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） TIMP-2與TIMP-1一樣是基質(zhì)金屬蛋白酶的抑制酶，其功能與MMP相反，能抑制腫瘤細(xì)胞的浸潤(rùn)和轉(zhuǎn)移，主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-2又稱(chēng)為CSC-21K，是一種21-24kDa的糖蛋白，在多種組織細(xì)胞中表達(dá)，它可以和MMPs家族成員以共價(jià)鍵方式形成復(fù)合物，從而發(fā)揮其抑制作用。在正常生理?xiàng)l件下，MMPs和TIMPs之間的平衡狀態(tài)是維持細(xì)胞外基質(zhì)正常狀態(tài)所必需的，一旦它們之間的比例失調(diào)，就會(huì)造成一系列的病理狀態(tài)。 |
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